OpenAccessBelV2, Main, Exploration, bibRecord, 000213

TR-DB: an open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis.

Identifieur interne : 000213 ( Main/Exploration ); précédent : 000212; suivant : 000214

TR-DB: an open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis.

Auteurs : Yuming Hu [Belgique] ; Pieter Callebert [Belgique] ; Ilse Vandemoortel [Belgique] ; Long Nguyen [Belgique] ; Dominique Audenaert [Belgique] ; Luc Verschraegen [Belgique] ; Filip Vandenbussche [Belgique] ; Dominique Van Der Straeten [Belgique]

Source :

Plant physiology and biochemistry : PPB [ 1873-2690 ] ; 2014.

RBID : pubmed:24441765

English descriptors

KwdEn :
- Amino Acids, Cyclic (genetics), Amino Acids, Cyclic (metabolism), Arabidopsis (genetics), Arabidopsis (metabolism), Arabidopsis Proteins (metabolism), Databases, Factual, Ethylenes (metabolism), Gene Expression Regulation, Plant, Hypocotyl (metabolism), Phenotype, Plant Growth Regulators (metabolism), Plant Roots (metabolism), Seedlings (metabolism).
MESH :
- chemical , genetics : Amino Acids, Cyclic.
- chemical , metabolism : Amino Acids, Cyclic, Arabidopsis Proteins, Ethylenes, Plant Growth Regulators.
- genetics : Arabidopsis.
- metabolism : Arabidopsis, Hypocotyl, Plant Roots, Seedlings.
- Databases, Factual, Gene Expression Regulation, Plant, Phenotype.

Abstract

Small molecules which act as hormone agonists or antagonists represent useful tools in fundamental research and are widely applied in agriculture to control hormone effects. High-throughput screening of large chemical compound libraries has yielded new findings in plant biology, with possible future applications in agriculture and horticulture. To further understand ethylene biosynthesis/signaling and its crosstalk with other hormones, we screened a 12,000 compound chemical library based on an ethylene-related bioassay of dark-grown Arabidopsis thaliana (L.) Heynh. seedlings. From the initial screening, 1313 (∼11%) biologically active small molecules altering the phenotype triggered by the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC), were identified. Selection and sorting in classes were based on the angle of curvature of the apical hook, the length and width of the hypocotyl and the root. A MySQL-database was constructed (https://chaos.ugent.be/WE15/) including basic chemical information on the compounds, images illustrating the phenotypes, phenotype descriptions and classification. The research perspectives for different classes of hit compounds will be evaluated, and some general screening tips for customized high-throughput screening and pitfalls will be discussed.

DOI: 10.1016/j.plaphy.2013.12.008
PubMed: 24441765

Affiliations:

Belgique

Le document en format XML

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<front><div type="abstract" xml:lang="en">Small molecules which act as hormone agonists or antagonists represent useful tools in fundamental research and are widely applied in agriculture to control hormone effects. High-throughput screening of large chemical compound libraries has yielded new findings in plant biology, with possible future applications in agriculture and horticulture. To further understand ethylene biosynthesis/signaling and its crosstalk with other hormones, we screened a 12,000 compound chemical library based on an ethylene-related bioassay of dark-grown Arabidopsis thaliana (L.) Heynh. seedlings. From the initial screening, 1313 (∼11%) biologically active small molecules altering the phenotype triggered by the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC), were identified. Selection and sorting in classes were based on the angle of curvature of the apical hook, the length and width of the hypocotyl and the root. A MySQL-database was constructed (https://chaos.ugent.be/WE15/) including basic chemical information on the compounds, images illustrating the phenotypes, phenotype descriptions and classification. The research perspectives for different classes of hit compounds will be evaluated, and some general screening tips for customized high-throughput screening and pitfalls will be discussed.</div>
</front>
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Serveur d'exploration autour du libre accès en Belgique

TR-DB: an open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis.

TR-DB: an open-access database of compounds affecting the ethylene-induced triple response in Arabidopsis.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration autour du libre accès en Belgique
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